(1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Before filling into hard gelatine capsules, 2500 g of the thus obtained lacquered active agent pellets were screened under addition of 15 g microfine talc. The particle size fraction of 0.7 mm to 1.25 mm (2450 g, corresponding to 98.0% of the theoretical amount) has a content of 18.5% of propiverine-hydrochloride as determined according to Example 6. The content of citric acid was determined by means of the titration as described in Example 6 to be 49%. Thus the result is a molar ratio of propiverine to citric acid of 1:5.6, which is in the typical range.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Before filling into hard gelatine capsules, 2500 g of the thus obtained lacquered active agent pellets were screened under addition of 15 g microfine talc. The particle size fraction of 0.7 mm to 1.25 mm (2450 g, corresponding to 98.0% of the theoretical amount) has a content of 18.5% of propiverine-hydrochloride as determined according to Example 6. The content of citric acid was determined by means of the titration as described in Example 6 to be 49%. Thus the result is a molar ratio of propiverine to citric acid of 1:5.6, which is in the typical range.