2-ethylpropanediamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Amino-4-(1,3-benzodioxol-5-yl)-6-(phenylsulfanyl)-3,5-dicyanopyridine (5.00 g, 13.43 mmol) [preparation analogously to J. M. Quintela, J. L. Soto, Anales de Quimica 79, 368–372 (1983)] is initially charged with ethyl malonamide (4.23 g, 23.22 mmol) in absolute DMF (30 ml) under an atmosphere of argon. Potassium tert-butoxide (3.01 g, 26.85 mmol) is added, and the solution is then stirred at room temperature for 22 hours. The mixture is poured into water (300 ml). The mixture is then extracted three times with ethyl acetate (300 ml each) and the combined organic phases are dried over magnesium sulfate, filtered and concentrated to about 100 ml. The precipitated crystals are filtered off with suction. The mixture is then extracted three times with ethyl acetate (300 ml each) the combined organic phases are dried over magnesium sulfate filtered concentrated to about 100 ml The precipitated crystals are filtered off with suction