表示可能な構造データがありません
ClC([H])([H])C([H])([H])C([H])([H])S(N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(=O)=O製品情報
N-tert-butyl-3-chloropropane-1-sulfonamide (CAS 63132-85-4) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 11701296
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-994cf0f9618c46f8bb2f2a11b4314948反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-0c8a5931329449fab903e48017f43447反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-58fba09e972841a19171c92fbe4c7a0d反応条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A solution of N-tert-butyl-(3-chloro)propylsulfonamide (4.3 g, 20 mmol) was dissolved in dry THF (100 mL) and cooled to −78° C. To this solution was added n-BuLi (17.6 mL, 44 mmol, 2.5 M in hexane) slowly. The dry ice bath was removed and the reaction mixture was allowed to warm to rt over a period of 1.5 h. This mixture was then cooled to −78° C., and a solution of n-BuLi (20 mmol, 8 mL, 2.5 M in hexane) was added. The reaction mixture was warmed to rt, recooled to −78° C. over a period of 2 h and a neat solution of methyl iodide (5.68 g, 40 mmol) added. The reaction mixture was allowed to warm to rt overnight, quenched with saturated NH4Cl (100 mL) at rt. It was extracted with EtOAc (100 mL). The organic phase was washed with brine (100 mL), dried (MgSO4), and concentrated in vacuo to give a yellow oil which was crystallized from hexane to afford the product as a slightly yellow solid (3.1 g, 81%): 1H NMR (CDCl3) δ 0.79 (m, 2H), 1.36 (s, 9H), 1.52 (m, 2H), 1.62 (s, 3H), 4.10 (bs, 1H). The dry ice bath was removed to warm to rt over a period of 1.5 h This mixture was then cooled to −78° C. The reaction mixture was warmed to rt to warm to rt overnight quenched with saturated NH4Cl (100 mL) at rt It was extracted with EtOAc (100 mL) The organic phase was washed with brine (100 mL) dried (MgSO4) concentrated in vacuo to give a yellow oil which was crystallized from hexane
ソース ID: ord-5a6d61a506144cb6ae560b60dce21783反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of N-tert-butyl-(3-chloro)propylsulfonamide (2.14 g, 10.0 mmol) in THF (100 mL) was added n-BuLi (2.5 M in hexane, 8.0 mL, 20.0 mmol) at −78° C. The reation mixture was allowed to warm up to room temperature over period of 1 h. The volatiles were removed in vacuo. The residue was partitioned between EtOAC and water (200 mL, 200 mL). The separated organic phase was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was recrystallized from hexane to yield the desired product as a white solid (1.0 g, 56%). The volatiles were removed in vacuo The residue was partitioned between EtOAC and water (200 mL, 200 mL) The separated organic phase was washed with brine dried over Na2SO4 filtered concentrated in vacuo The residue was recrystallized from hexane
ソース ID: ord-b5023b00f3ac4e03b293d0dba5d06f43反応条件: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: tert-Butylamine (3.0 mol, 315.3 mL) was dissolved in THF (2.5 L). The solution was cooled to −20° C. 3-Chloropropanesulfonyl chloride (1.5 mol, 182.4 mL) was added slowly. The reaction mixture was allowed to warm to rt and stirred for 24 h. The mixture was filtered, and the filtrate was concentrated in vacuo. The residue was dissolved in CH2Cl2 (2.0 L). The resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L) and dried over Na2SO4. It was filtered and concentrated in vacuo to give a slightly yellow solid, which was crystallized from hexane to afford the product as a white solid (316.0 g, 99%). to warm to rt The mixture was filtered the filtrate was concentrated in vacuo The residue was dissolved in CH2Cl2 (2.0 L) The resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L) dried over Na2SO4 It was filtered concentrated in vacuo to give a slightly yellow solid, which was crystallized from hexane
ソース ID: ord-9688b73ee5194cbfa430e4fd8885c2b0反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of N-tert-butyl-(3-chloro)propylsulfonamide (2.14 g, 10.0 mmol) in THF (100 mL) was added n-BuLi (2.5 M in hexane, 8.0 mL, 20.0 mmol) at −78° C. The reaction mixture was allowed to warm up to room temperature over period of 1 h. The volatiles were removed in vacuo. The residue was partitioned between EtOAC and water (200 mL, 200 mL). The separated organic phase was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was recrystallized from hexane to yield the desired product as a white solid (1.0 g, 56%). The volatiles were removed in vacuo The residue was partitioned between EtOAC and water (200 mL, 200 mL) The separated organic phase was washed with brine dried over Na2SO4 filtered concentrated in vacuo The residue was recrystallized from hexane
ソース ID: ord-5f0473953fab46668f705a9dd975081f反応条件: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: tert-Butylamine (3.0 mol, 315.3 mL) was dissolved in THF (2.5 L). The solution was cooled to −20° C. 3-Chloropropanesulfonyl chloride (1.5 mol, 182.4 mL) was added slowly. The reaction mixture was allowed to warm to rt and stirred for 24 h. The mixture was filtered, and the filtrate was concentrated in vacuo. The residue was dissolved in CH2Cl2 (2.0 L). The resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L) and dried over Na2SO4. It was filtered and concentrated in vacuo to give a slightly yellow solid, which was crystallized from hexane to afford the product as a white solid (316.0 g, 99%). to warm to rt The mixture was filtered the filtrate was concentrated in vacuo The residue was dissolved in CH2Cl2 (2.0 L) The resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L) dried over Na2SO4 It was filtered concentrated in vacuo to give a slightly yellow solid, which was crystallized from hexane
ソース ID: ord-44342623ba364fcea5d05df4a37fb283反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of N-tert-butyl-(3-chloro)propylsulfonamide (2.14 g, 10.0 mmol) in THF (100 mL) was added n-BuLi (2.5 M in hexane, 8.0 mL, 20.0 mmol) at −78° C. The reaction mixture was allowed to warm up to room temperature over period of 1 h. The volatiles were removed in vacuo. The residue was partitioned between EtOAC and water (200 mL, 200 mL). The separated organic phase was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was recrystallized from hexane to yield the desired product as a white solid (1.0 g, 56%). The volatiles were removed in vacuo The residue was partitioned between EtOAC and water (200 mL, 200 mL) The separated organic phase was washed with brine dried over Na2SO4 filtered concentrated in vacuo The residue was recrystallized from hexane
ソース ID: ord-2aa3c996856549a9afec02f1f09d9805反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: To a solution of N-tert-butyl-(3-chloro)propylsulfonamide (2.14 g, 10.0 mmol) in THF (100 mL) was added n-BuLi (2.5 M in hexane, 8.0 mL, 20.0 mmol) at −78° C. The reaction mixture was allowed to warm up to room temperature over period of 1 h. The volatiles were removed in vacuo. The residue was partitioned between EtOAC and water (200 mL, 200 mL). The separated organic phase was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was recrystallized from hexane to yield the desired product as a white solid (1.0 g, 56%). The volatiles were removed in vacuo The residue was partitioned between EtOAC and water (200 mL, 200 mL) The separated organic phase was washed with brine dried over Na2SO4 filtered concentrated in vacuo The residue was recrystallized from hexane
ソース ID: ord-2aa3c996856549a9afec02f1f09d9805反応条件: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: tert-Butylamine (3.0 mol, 315.3 mL) was dissolved in THF (2.5 L). The solution was cooled to −20° C. 3-Chloropropanesulfonyl chloride (1.5 mol, 182.4 mL) was added slowly. The reaction mixture was allowed to warm to rt and stirred for 24 h. The mixture was filtered, and the filtrate was concentrated in vacuo. The residue was dissolved in CH2Cl2 (2.0 L). The resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L) and dried over Na2SO4. It was filtered and concentrated in vacuo to give a slightly yellow solid, which was crystallized from hexane to afford the product as a white solid (316.0 g, 99%). to warm to rt The mixture was filtered the filtrate was concentrated in vacuo The residue was dissolved in CH2Cl2 (2.0 L) The resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L) dried over Na2SO4 It was filtered concentrated in vacuo to give a slightly yellow solid, which was crystallized from hexane
ソース ID: ord-2280f2103aba47e98281a3cc15a99bc5反応条件: temp:-20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: tert-Butylamine (3.0 mol, 315.3 mL) was dissolved in THF (2.5 L). The solution was cooled to −20° C. 3-Chloropropanesulfonyl chloride (1.5 mol, 182.4 mL) was added slowly. The reaction mixture was allowed to warm to rt and stirred for 24 h. The mixture was filtered, and the filtrate was concentrated in vacuo. The residue was dissolved in CH2Cl2 (2.0 L). The resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L) and dried over Na2SO4. It was filtered and concentrated in vacuo to give a slightly yellow solid, which was crystallized from hexane to afford the product as a white solid (316.0 g, 99%). to warm to rt The mixture was filtered the filtrate was concentrated in vacuo The residue was dissolved in CH2Cl2 (2.0 L) The resulting solution was washed with 1 N HCl (1.0 L), water (1.0 L), brine (1.0 L) dried over Na2SO4 It was filtered concentrated in vacuo to give a slightly yellow solid, which was crystallized from hexane
ソース ID: ord-2280f2103aba47e98281a3cc15a99bc5PubChem References
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