cyclooctanamine;hydrochloride

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 2g of 7-chloro-6-(2-chloroethyl)-5-methyl-s-triazolo[1,5-a]pyrimidine, 1.45g of cyclooctylamine hydrochloride, 4 ml of triethylamine and 20 ml of isopropyl alcohol was stirred under reflux for 1.5 hours, and treated thereafter as described in Example 5. The crystals thus obtained were recrystallized from ethanol to give 1.25g of colorless needles of m.p. 188.5° - 190.5° C. under reflux for 1.5 hours treated The crystals thus obtained were recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 2g of 7-chloro-6-(2-chloroethyl)-5-methyl-s-triazolo[1,5-a]pyrimidine, 1.45g of cyclooctylamine hydrochloride, 4 ml of triethylamine and 20 ml of isopropyl alcohol was stirred under reflux for 1.5 hours, and treated thereafter as described in Example 5. The crystals thus obtained were recrystallized from ethanol to give 1.25g of colorless needles of m.p. 188.5° - 190.5° C. under reflux for 1.5 hours treated The crystals thus obtained were recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 2g of 7-chloro-6-(2-chloroethyl)-5-methyl-s-triazolo[1,5-a]pyrimidine, 1.45g of cyclooctylamine hydrochloride, 4 ml of triethylamine and 20 ml of isopropyl alcohol was stirred under reflux for 1.5 hours, and treated thereafter as described in Example 5. The crystals thus obtained were recrystallized from ethanol to give 1.25g of colorless needles of m.p. 188.5° - 190.5° C. under reflux for 1.5 hours treated The crystals thus obtained were recrystallized from ethanol