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CCN(CC)CCCC(=O)O製品情報
4-(diethylamino)butanoic acid (CAS 63867-13-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
想定用途
専門的研究・工業用途限定
データベース ID 44844
安全上の注意
For professional research and industrial use only. Review the supplier safety data sheet before handling.
合成データ
12 反応 · 12 文献
反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-bb9ed5fccbe3462898ae0801c7744f2e反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-eb3f62bfa66b497fb13bde0fae85c97d反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-bb9ed5fccbe3462898ae0801c7744f2e反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: N,N'-Carbonyldiimidazole (11.2 g) was added to a suspension of 4-(N,N-diethylamino)butanoic acid (10.0 g) in tetrahydrofuran (400 ml), and the mixture was stirred at room temperature for 6 hours. Then monoethyl malonate magnesium salt (Mg(OCOCH2COOC2H5)2)(19.8 g) was added, and the mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in chloroform. The chloroform layer was washed with water and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel. The fractions eluted with chloroform-methanol (5:1, v/v) gave ethyl 6-(N,N-diethylamino)-3-oxohexanoate (7.6 g, 53%). the mixture was stirred at room temperature for 14 hours The reaction mixture was concentrated under reduced pressure the residue was dissolved in chloroform The chloroform layer was washed with water dried over magnesium sulfate the solvent was evaporated under reduced pressure The fractions eluted with chloroform-methanol (5:1
ソース ID: ord-1aa01b3a962a409bae844d5545a2ce98反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: N,N'-Carbonyldiimidazole (11.2 g) was added to a suspension of 4-(N,N-diethylamino)butanoic acid (10.0 g) in tetrahydrofuran (400 ml), and the mixture was stirred at room temperature for 6 hours. Then monoethyl malonate magnesium salt (Mg(OCOCH2COOC2H5)2)(19.8 g) was added, and the mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in chloroform. The chloroform layer was washed with water and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel. The fractions eluted with chloroform-methanol (5:1, v/v) gave ethyl 6-(N,N-diethylamino)-3-oxohexanoate (7.6 g, 53%). the mixture was stirred at room temperature for 14 hours The reaction mixture was concentrated under reduced pressure the residue was dissolved in chloroform The chloroform layer was washed with water dried over magnesium sulfate the solvent was evaporated under reduced pressure The fractions eluted with chloroform-methanol (5:1
ソース ID: ord-1aa01b3a962a409bae844d5545a2ce98反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of benzyl 4-(N,N-diethylamino)butanoate (33.8 g), palladium-carbon (5%, 7 g) and ethanol (500 ml) was subjected to catalytic hydrogenation at room temperature and 1 atm. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give 4-(N,N-diethylamino)butanoic acid (16.2 g, 75%). mp. 45°-47° C. was subjected to catalytic hydrogenation at room temperature The catalyst was filtered off the filtrate was concentrated under reduced pressure
ソース ID: ord-202be315fad54cc1b36e00ad8c2182b2反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of benzyl 4-(N,N-diethylamino)butanoate (33.8 g), palladium-carbon (5%, 7 g) and ethanol (500 ml) was subjected to catalytic hydrogenation at room temperature and 1 atm. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give 4-(N,N-diethylamino)butanoic acid (16.2 g, 75%). mp. 45°-47° C. was subjected to catalytic hydrogenation at room temperature The catalyst was filtered off the filtrate was concentrated under reduced pressure
ソース ID: ord-202be315fad54cc1b36e00ad8c2182b2反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: N,N'-Carbonyldiimidazole (11.2 g) was added to a suspension of 4-(N,N-diethylamino)butanoic acid (10.0 g) in tetrahydrofuran (400 ml), and the mixture was stirred at room temperature for 6 hours. Then monoethyl malonate magnesium salt (Mg(OCOCH2COOC2H5)2)(19.8 g) was added, and the mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in chloroform. The chloroform layer was washed with water and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel. The fractions eluted with chloroform-methanol (5:1, v/v) gave ethyl 6-(N,N-diethylamino)-3-oxohexanoate (7.6 g, 53%). the mixture was stirred at room temperature for 14 hours The reaction mixture was concentrated under reduced pressure the residue was dissolved in chloroform The chloroform layer was washed with water dried over magnesium sulfate the solvent was evaporated under reduced pressure The fractions eluted with chloroform-methanol (5:1
ソース ID: ord-1aa01b3a962a409bae844d5545a2ce98反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of benzyl 4-(N,N-diethylamino)butanoate (33.8 g), palladium-carbon (5%, 7 g) and ethanol (500 ml) was subjected to catalytic hydrogenation at room temperature and 1 atm. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give 4-(N,N-diethylamino)butanoic acid (16.2 g, 75%). mp. 45°-47° C. was subjected to catalytic hydrogenation at room temperature The catalyst was filtered off the filtrate was concentrated under reduced pressure
ソース ID: ord-202be315fad54cc1b36e00ad8c2182b2反応条件: temp:0.00; pressure:0.00; stir:
ソース ID: ord-eb3f62bfa66b497fb13bde0fae85c97d反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: N,N'-Carbonyldiimidazole (11.2 g) was added to a suspension of 4-(N,N-diethylamino)butanoic acid (10.0 g) in tetrahydrofuran (400 ml), and the mixture was stirred at room temperature for 6 hours. Then monoethyl malonate magnesium salt (Mg(OCOCH2COOC2H5)2)(19.8 g) was added, and the mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in chloroform. The chloroform layer was washed with water and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel. The fractions eluted with chloroform-methanol (5:1, v/v) gave ethyl 6-(N,N-diethylamino)-3-oxohexanoate (7.6 g, 53%). the mixture was stirred at room temperature for 14 hours The reaction mixture was concentrated under reduced pressure the residue was dissolved in chloroform The chloroform layer was washed with water dried over magnesium sulfate the solvent was evaporated under reduced pressure The fractions eluted with chloroform-methanol (5:1
ソース ID: ord-1aa01b3a962a409bae844d5545a2ce98反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
実験手順: A mixture of benzyl 4-(N,N-diethylamino)butanoate (33.8 g), palladium-carbon (5%, 7 g) and ethanol (500 ml) was subjected to catalytic hydrogenation at room temperature and 1 atm. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give 4-(N,N-diethylamino)butanoic acid (16.2 g, 75%). mp. 45°-47° C. was subjected to catalytic hydrogenation at room temperature The catalyst was filtered off the filtrate was concentrated under reduced pressure
ソース ID: ord-202be315fad54cc1b36e00ad8c2182b2PubChem References
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