17-beta-Hydroxy-5alpha-androst-1-en-3-one acetate

反応条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3.3 g (10 mmol) of 17β-acetoxy-5α-androst-1-en-3-one in 15 ml of ethyl acetate and 143 mg (0.1 mmol) of CuBr are added to solution a). It is stirred for 16 hours at 25° C. The reaction solution is hydrolyzed with 1 ml of water, stirred for 15 minutes more and the inorganic solid is filtered off. The solid is washed with ethyl acetate. After evaporation of the solvent, 3.5 g of substance is obtained that is recrystallized from acetone. After suctioning off of the crystals, 2.9 g of 17-acetoxy-1α-methyl-5α-androstan-3-one of a melting point of 179-180° C. is obtained. stirred for 15 minutes more the inorganic solid is filtered off The solid is washed with ethyl acetate After evaporation of the solvent, 3.5 g of substance is obtained that is recrystallized from acetone is obtained