2-(4-chlorophenyl)phenol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 280 g (2 mols) of powdered potassium carbonate were suspended in 2 l. of methyl ethyl ketone. 409 g (2 mols) of 4'-chloro-hydroxybiphenyl were added and the mixture was heated to the boil. Thereafter 260 g (2 mols) of α-chloropinacolone were added dropwise over the course of 1 hour and the mixture was heated under reflux for 15 hours. After cooling, the solid residue was filtered off, washed and recrystallised from ligroin. 513 g (79% of theory) of [1-(4'-(4"-chlorophenyl)-phenoxy]-3,3-dimethyl-butan-2-one of melting point 90° C. are obtained. the mixture was heated to the boil the mixture was heated under reflux for 15 hours After cooling the solid residue was filtered off washed recrystallised from ligroin

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 280 g (2 mols) of powdered potassium carbonate were suspended in 2 l. of methyl ethyl ketone. 409 g (2 mols) of 4'-chloro-hydroxybiphenyl were added and the mixture was heated to the boil. Thereafter 260 g (2 mols) of α-chloropinacolone were added dropwise over the course of 1 hour and the mixture was heated under reflux for 15 hours. After cooling, the solid residue was filtered off, washed and recrystallised from ligroin. 513 g (79% of theory) of [1-(4'-(4"-chlorophenyl)-phenoxy]-3,3-dimethyl-butan-2-one of melting point 90° C. are obtained. the mixture was heated to the boil the mixture was heated under reflux for 15 hours After cooling the solid residue was filtered off washed recrystallised from ligroin

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 280 g (2 mols) of powdered potassium carbonate were suspended in 2 l. of methyl ethyl ketone. 409 g (2 mols) of 4'-chloro-hydroxybiphenyl were added and the mixture was heated to the boil. Thereafter 260 g (2 mols) of α-chloropinacolone were added dropwise over the course of 1 hour and the mixture was heated under reflux for 15 hours. After cooling, the solid residue was filtered off, washed and recrystallised from ligroin. 513 g (79% of theory) of [1-(4'-(4"-chlorophenyl)-phenoxy]-3,3-dimethyl-butan-2-one of melting point 90° C. are obtained. the mixture was heated to the boil the mixture was heated under reflux for 15 hours After cooling the solid residue was filtered off washed recrystallised from ligroin

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 280 g (2 mols) of powdered potassium carbonate were suspended in 2 l of methyl ethyl ketone. 409 g (2 mols) of 4' -chlorohydroxybiphenyl were added and the mixture was heated to the boil. Thereafter 269 g (2 mols) of α-chloropinacolone were added dropwise over the course of 1 hour and the mixture was heated for 15 hours under reflux. After cooling, the solid residue was filtered off, washed and recrystallized from ligroin. 513 g (79% of theory) of 1-[4-(4-chlorophenyl)phenoxy]-3,3-dimethylbutan-2-one of melting point 90° C were obtained. the mixture was heated to the boil the mixture was heated for 15 hours under reflux After cooling the solid residue was filtered off washed recrystallized from ligroin