2-[di(propan-2-yl)amino]acetic acid;hydrochloride

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 3.82 g (19.5 mMol) diisopropylamino-acetic acid hydrochloride (3), in 50 ml DMF, was added to 2.24 g (19.5 mMol) N-hydroxysuccinimide and 8.04 g (39 nMol) dicyclohexylcarbodiimide. The reaction mixture was stirred for 16 h at RT. The residue was filtered and the filtrate was evaporated in vacuum to dryness. After dissolving the residue in CH2Cl2, the solution was washed with NaHCO3, dried (sodium sulphate) and the solvent evaporated. The compound was then recrystallised from diisopropylether. The residue was filtered the filtrate was evaporated in vacuum to dryness After dissolving the residue in CH2Cl2 the solution was washed with NaHCO3 dried (sodium sulphate) the solvent evaporated The compound was then recrystallised from diisopropylether

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 5.4 g (25 mMol) diisopropylamino-acetic acid tert-butylester 2 was stirred with 6.25 ml (75 mMol) 12 M HCl in 25 ml water for 2.5 h at 60° C. After distillation in vacuo of water and excess of HCl, the residue was dried with toluene azeotropically. After distillation in vacuo of water excess of HCl, the residue was dried with toluene azeotropically

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 5.4 g (25 mMol) diisopropylamino-acetic acid tert-butylester 2 was stirred with 6.25 ml (75 mMol) 12 M HCl in 25 ml water for 2.5 h at 60° C. After distillation in vacuo of water and excess of HCl, the residue was dried with toluene azeotropically. After distillation in vacuo of water excess of HCl, the residue was dried with toluene azeotropically