5-bromo-1,3-difluoro-2-methylsulfonylbenzene

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Combine 5-bromo-1,3-difluoro-2-methylsulfanyl-benzene (1.1 g, 4.6 mmol), oxone (11 g, 18.4 mmol) and methanol (20 mL). Stir for 12 hours. Filter the suspension and evaporate the filtrate. Dissolve the residue in dichloromethane (100 mL) and add water (100 mL). Separate the organic layer and wash with brine (50 mL). Dry with MgSO4, filter and concentrate in vacuo. Chromatograph the residue on a column eluting the material with diethyl ether in hexane (0 to 5%) to give 497 mg of the title compound (40%). Filter the suspension evaporate the filtrate Dissolve the residue in dichloromethane (100 mL) add water (100 mL) Separate the organic layer wash with brine (50 mL) Dry with MgSO4 filter concentrate in vacuo Chromatograph the residue on a column eluting the material with diethyl ether in hexane (0 to 5%)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Combine 5-bromo-1,3-difluoro-2-methylsulfanyl-benzene (1.1 g, 4.6 mmol), oxone (11 g, 18.4 mmol) and methanol (20 mL). Stir for 12 hours. Filter the suspension and evaporate the filtrate. Dissolve the residue in dichloromethane (100 mL) and add water (100 mL). Separate the organic layer and wash with brine (50 mL). Dry with MgSO4, filter and concentrate in vacuo. Chromatograph the residue on a column eluting the material with diethyl ether in hexane (0 to 5%) to give 497 mg of the title compound (40%). Filter the suspension evaporate the filtrate Dissolve the residue in dichloromethane (100 mL) add water (100 mL) Separate the organic layer wash with brine (50 mL) Dry with MgSO4 filter concentrate in vacuo Chromatograph the residue on a column eluting the material with diethyl ether in hexane (0 to 5%)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Combine 5-bromo-1,3-difluoro-2-methylsulfanyl-benzene (1.1 g, 4.6 mmol), oxone (11 g, 18.4 mmol) and methanol (20 mL). Stir for 12 hours. Filter the suspension and evaporate the filtrate. Dissolve the residue in dichloromethane (100 mL) and add water (100 mL). Separate the organic layer and wash with brine (50 mL). Dry with MgSO4, filter and concentrate in vacuo. Chromatograph the residue on a column eluting the material with diethyl ether in hexane (0 to 5%) to give 497 mg of the title compound (40%). Filter the suspension evaporate the filtrate Dissolve the residue in dichloromethane (100 mL) add water (100 mL) Separate the organic layer wash with brine (50 mL) Dry with MgSO4 filter concentrate in vacuo Chromatograph the residue on a column eluting the material with diethyl ether in hexane (0 to 5%)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Combine 5-bromo-1,3-difluoro-2-methylsulfanyl-benzene (1.1 g, 4.6 mmol), oxone (11 g, 18.4 mmol) and methanol (20 mL). Stir for 12 hours. Filter the suspension and evaporate the filtrate. Dissolve the residue in dichloromethane (100 mL) and add water (100 mL). Separate the organic layer and wash with brine (50 mL). Dry with MgSO4, filter and concentrate in vacuo. Chromatograph the residue on a column eluting the material with diethyl ether in hexane (0 to 5%) to give 497 mg of the title compound (40%). Filter the suspension evaporate the filtrate Dissolve the residue in dichloromethane (100 mL) add water (100 mL) Separate the organic layer wash with brine (50 mL) Dry with MgSO4 filter concentrate in vacuo Chromatograph the residue on a column eluting the material with diethyl ether in hexane (0 to 5%)