4-(4-methoxyphenyl)-2-methylbutan-2-amine

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was prepared from 3-chloromandelic acid (2.1 g) and 3-(4-methoxyphenyl)-1,1-dimethylpropanamine (1.9 g) by an analogous procedure to that described in Description 12 and used without further purification. used without further purification

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 509 mg (3.13 mmol) of (R)-2-(tetrazolo[1,5-a]pyrid-6-yl)oxirane and 619 mg (3.21 mmol) of 2-amino-2-methyl-4-(4-methoxyphenyl)butane in 25 ml of absolute ethanol was heated at reflux for two hours and then stirred overnight at room temperature. The reaction mixture was concentrated and the residue chromatographed on silica gel (4:1:2 ethyl acetate:n-propanol:water with 1% NH4OH) to give 497 mg of product. Recrystallization from isopropanol afforded 357 mg of crystalline tetrazole, mp. 139-40° C. at reflux for two hours The reaction mixture was concentrated the residue chromatographed on silica gel (4:1:2 ethyl acetate:n-propanol:water with 1% NH4OH)