1-Chloro-2-fluoro-3-isocyanatobenzene

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In analogy to the procedure described in example 58F, (R)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-2-methyl-[1,4]diazepan-5-one dihydrochloride (example 58E) and 3-chloro-2-fluorophenyl isocyanate (but with 2.1 eq. of isocyanate and 5 eq. of 4-methylmorpholine) gave after extraction with sat. aq. sodium hydrogencarbonate solution/1 M aq. sodium hydroxide solution and dichloromethane (3 times) 0.016 g (12%) of the title compound as white foam. MS: 467.2 (MH+, 1Cl). gave after extraction with sat. aq. sodium hydrogencarbonate solution/1 M aq. sodium hydroxide solution and dichloromethane (3 times) 0.016 g (12%) of the title compound as white foam

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In analogy to the procedure described in example 58F, (R)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-2-methyl-[1,4]diazepan-5-one dihydrochloride (example 58E) and 3-chloro-2-fluorophenyl isocyanate (but with 2.1 eq. of isocyanate and 5 eq. of 4-methylmorpholine) gave after extraction with sat. aq. sodium hydrogencarbonate solution/1 M aq. sodium hydroxide solution and dichloromethane (3 times) 0.016 g (12%) of the title compound as white foam. MS: 467.2 (MH+, 1Cl). gave after extraction with sat. aq. sodium hydrogencarbonate solution/1 M aq. sodium hydroxide solution and dichloromethane (3 times) 0.016 g (12%) of the title compound as white foam

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In analogy to the procedure described in example 58F, (R)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-2-methyl-[1,4]diazepan-5-one dihydrochloride (example 58E) and 3-chloro-2-fluorophenyl isocyanate (but with 2.1 eq. of isocyanate and 5 eq. of 4-methylmorpholine) gave after extraction with sat. aq. sodium hydrogencarbonate solution/1 M aq. sodium hydroxide solution and dichloromethane (3 times) 0.016 g (12%) of the title compound as white foam. MS: 467.2 (MH+, 1Cl). gave after extraction with sat. aq. sodium hydrogencarbonate solution/1 M aq. sodium hydroxide solution and dichloromethane (3 times) 0.016 g (12%) of the title compound as white foam