1-(4-aminophenyl)propan-1-one

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture containing 14.9 g. (0.1 m) of p-aminopropiophenone 21.7 g. (0.1 m.) of the compound of Example I, C. and 500 ml. of ethanol was refluxed with stirring overnight. It was then concentrated in vacuo to give 34 g. m.p. 287°-289°, complete 320°C. The crude product was recrystallized from 1000 ml. of MeOH to yield 27 g.m.p. softens 318°, melts 328°-330°C. A mixture containing 14.9 g It was then concentrated in vacuo to give 34 g m.p. 287°-289°, complete 320°C The crude product was recrystallized from 1000 ml of MeOH to yield 27 g softens 318° melts 328°-330°C.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture containing 14.9 g. (0.1 m) of p-aminopropiophenone 21.7 g. (0.1 m.) of the compound of Example I, C. and 500 ml. of ethanol was refluxed with stirring overnight. It was then concentrated in vacuo to give 34 g. m.p. 287°-289°, complete 320°C. The crude product was recrystallized from 1000 ml. of MeOH to yield 27 g.m.p. softens 318°, melts 328°-330°C. A mixture containing 14.9 g It was then concentrated in vacuo to give 34 g m.p. 287°-289°, complete 320°C The crude product was recrystallized from 1000 ml of MeOH to yield 27 g softens 318° melts 328°-330°C.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture containing 14.9 g. (0.1 m) of p-aminopropiophenone 21.7 g. (0.1 m.) of the compound of Example I, C. and 500 ml. of ethanol was refluxed with stirring overnight. It was then concentrated in vacuo to give 34 g. m.p. 287°-289°, complete 320°C. The crude product was recrystallized from 1000 ml. of MeOH to yield 27 g.m.p. softens 318°, melts 328°-330°C. A mixture containing 14.9 g It was then concentrated in vacuo to give 34 g m.p. 287°-289°, complete 320°C The crude product was recrystallized from 1000 ml of MeOH to yield 27 g softens 318° melts 328°-330°C.

反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To 400 ml of toluene are added 30 g of 1-(4-aminophenyl)propan-1-one and 38 ml (402 mM) of acetic anhydride. The reaction medium is heated at 60° C. with stirring for 1 hour. A solid precipitates out. After filtration and washing with toluene, 37.9 g of N-(4-propanoylphenyl)acetamide are obtained in the form of a white powder. A solid precipitates out After filtration washing with toluene, 37.9 g of N-(4-propanoylphenyl)acetamide are obtained in the form of a white powder

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 141 g (1 mole) of p-propionylacetanilide were dissolved while refluxing and stirring into 600 ml of 5 N hydrochloric acid. Refluxing was continued for 30 min, cooling was applied, and sodium carbonate (about 300 g) was added, until the reaction mixture was alkaline. The residue formed was sucked off, washed with water until neutral and recrystallized from 725 ml of isopropanol. The mixture was sucked off and washed with ether. After drying under vacuum, a yellow-brownish powder was obtained. while refluxing Refluxing cooling The residue formed washed with water until neutral and recrystallized from 725 ml of isopropanol washed with ether After drying under vacuum a yellow-brownish powder was obtained

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 1-(4'-aminophenyl)-propan-1-one (30 g, 0.2 mol), phthalic anhydride (60 g, 0.4 mol) and of acetic acid (300 ml) is heated at reflux for 2 h. The reaction mixture is cooled to room temperature and the precipitate consisting of 1-(4'-phthalimidophenyl)-propan-1-one (41 g, 0.150 mol, yield 75%) is filtered and dried in vacuo at reflux for 2 h

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture containing 14.9 g. (0.1 m) of p-aminopropiophenone 21.7 g. (0.1 m.) of the compound of Example I, C. and 500 ml. of ethanol was refluxed with stirring overnight. It was then concentrated in vacuo to give 34 g. m.p. 287°-289°, complete 320°C. The crude product was recrystallized from 1000 ml. of MeOH to yield 27 g.m.p. softens 318°, melts 328°-330°C. A mixture containing 14.9 g It was then concentrated in vacuo to give 34 g m.p. 287°-289°, complete 320°C The crude product was recrystallized from 1000 ml of MeOH to yield 27 g softens 318° melts 328°-330°C.