ethyl 2-(2-oxopyrrolidin-1-yl)propanoate

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: From 9.25 g. of ethyl α-methyl-2-oxo-1-pyrrolidineacetate and 10.5 g. of cis-3-(2,6-dimethyl-1-piperidinyl)propylamine, following the procedure of Example 21, there is obtained cis-(±)-N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-α-methyl-2-oxo-1-pyrrolidineacetamide; b.p. 165°-170° C./0.1 mm.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 9.25 g. of ethyl α-methyl-2-oxo-1-pyrrolidineacetate (British Pat. No. 1,309,692) and 11.2 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is heated under nitrogen and an air condenser plugged with cotton for 20 hours at 150° C. The excess cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is evaporated at reduced pressure and the residue is fractionated. The product, cis-(±)-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-α-methyl-2-oxo-1-pyrrolidineacetamide, is obtained as an oil, b.p. 168°-170° C./0.1 mm. A mixture of 9.25 g The excess cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is evaporated at reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: From 9.25 g. of ethyl α-methyl-2-oxo-1-pyrrolidineacetate and 10.5 g. of cis-3-(2,6-dimethyl-1-piperidinyl)propylamine, following the procedure of Example 21, there is obtained cis-(±)-N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-α-methyl-2-oxo-1-pyrrolidineacetamide; b.p. 165°-170° C./0.1 mm.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 9.25 g. of ethyl α-methyl-2-oxo-1-pyrrolidineacetate (British Pat. No. 1,309,692) and 11.2 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is heated under nitrogen and an air condenser plugged with cotton for 20 hours at 150° C. The excess cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is evaporated at reduced pressure and the residue is fractionated. The product, cis-(±)-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-α-methyl-2-oxo-1-pyrrolidineacetamide, is obtained as an oil, b.p. 168°-170° C./0.1 mm. A mixture of 9.25 g The excess cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is evaporated at reduced pressure