methyl 2-hydroxyoctanoate

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil. the reaction mixture was evaporated under reduced pressure The residue was partitioned between ethyl acetate and water The organic layer was washed with aqueous NaHCO3 solution dried over sodium sulfate Evaporation of the solvent under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil. the reaction mixture was evaporated under reduced pressure The residue was partitioned between ethyl acetate and water The organic layer was washed with aqueous NaHCO3 solution dried over sodium sulfate Evaporation of the solvent under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil. the reaction mixture was evaporated under reduced pressure The residue was partitioned between ethyl acetate and water The organic layer was washed with aqueous NaHCO3 solution dried over sodium sulfate Evaporation of the solvent under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil. the reaction mixture was evaporated under reduced pressure The residue was partitioned between ethyl acetate and water The organic layer was washed with aqueous NaHCO3 solution dried over sodium sulfate Evaporation of the solvent under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(2,3-dihydroxypropyl)-N-hexadecylamine (1.0 g, 0.0032 mole) and potassium hydroxide (0.01 g, 0.18 mmole) were heated to 85° C. under vacuum and methyl-2-hydroxyoctanoate (0.55 g, 0.0032 mole) was heated and added dropwise to the reaction. The reaction was heated under vacuum for 6 hours. A waxy off-white solid was obtained (crude yield=1.39 g). The waxy solid was recrystalized from hot hexane (yield=0.88 g). was heated added dropwise to the reaction The reaction was heated under vacuum for 6 hours A waxy off-white solid was obtained (crude yield=1.39 g) The waxy solid was recrystalized from hot hexane (yield=0.88 g)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(2,3-dihydroxypropyl)-N-tetradecylamine (1.0 g, 0.0035 mole) and potassium hydroxide (0.01 g, 0.18 mmole) were heated to 85° C. under vacuum and methyl-2-hydroxyoctanoate (0.667 g, 0.0038 mole) was added dropwise to the reaction. The reaction was heated under vacuum for 5 hours. A waxy off-white solid was obtained (crude yield=1.33 g). The waxy solid was recrystalized from hot hexane (yield=0.4 g). was added dropwise to the reaction The reaction was heated under vacuum for 5 hours A waxy off-white solid was obtained (crude yield=1.33 g) The waxy solid was recrystalized from hot hexane (yield=0.4 g)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(2,3-dihydroxypropyl)-N-hexadecylamine (1.0 g, 0.0032 mole) and potassium hydroxide (0.01 g, 0.18 mmole) were heated to 85° C. under vacuum and methyl-2-hydroxyoctanoate (0.55 g, 0.0032 mole) was heated and added dropwise to the reaction. The reaction was heated under vacuum for 6 hours. A waxy off-white solid was obtained (crude yield=1.39 g). The waxy solid was recrystalized from hot hexane (yield=0.88 g). was heated added dropwise to the reaction The reaction was heated under vacuum for 6 hours A waxy off-white solid was obtained (crude yield=1.39 g) The waxy solid was recrystalized from hot hexane (yield=0.88 g)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(2,3-dihydroxypropyl)-N-dodecylamine (1.0 g, 0.0039 mole) and potassium hydroxide (0.01 g, 0.18 mmole) were heated to 85° C. under vacuum and methyl 2-hydroxyoctanoate (0.6718 g, 0.0039 mole) was added dropwise to the reaction. The reaction was heated under vacuum for 5 hours. A waxy off-white solid was obtained (crude yield=1.38 g). The waxy solid was recrystalized from hot hexane (yield=0.44 g). was added dropwise to the reaction The reaction was heated under vacuum for 5 hours A waxy off-white solid was obtained (crude yield=1.38 g) The waxy solid was recrystalized from hot hexane (yield=0.44 g)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: N-(2,3-dihydroxypropyl)-N-tetradecylamine (1.0 g, 0.0035 mole) and potassium hydroxide (0.01 g, 0.18 mmole) were heated to 85° C. under vacuum and methyl-2-hydroxyoctanoate (0.667 g, 0.0038 mole) was added dropwise to the reaction. The reaction was heated under vacuum for 5 hours. A waxy off-white solid was obtained (crude yield=1.33 g). The waxy solid was recrystalized from hot hexane (yield=0.4 g). was added dropwise to the reaction The reaction was heated under vacuum for 5 hours A waxy off-white solid was obtained (crude yield=1.33 g) The waxy solid was recrystalized from hot hexane (yield=0.4 g)