methyl (3S)-morpholine-3-carboxylate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Triethylamine (1.2 mL) was added to the above-obtained (2S)-2-amino-3-(2-chloroethoxy)propanoic acid methyl ester (726 mg) in methanol (10 mL), and the resultant mixture was refluxed under heat for 3 hours, and then cooled in air. The reaction solvent was removed under reduced pressure. Ethyl acetate was added to the residue, and insoluble matter was removed by filtration. The solvent of the filtrate was removed under reduced pressure, to thereby give the title compound as an oily product (467 mg, 80%). under heat for 3 hours cooled in air The reaction solvent was removed under reduced pressure Ethyl acetate was added to the residue, and insoluble matter was removed by filtration The solvent of the filtrate was removed under reduced pressure