1-azido-2-[2-(2-methoxyethoxy)ethoxy]ethane

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-azido-2-(2-(2-methoxyethoxy)ethoxy)ethane (7.0 g, 37.0 mmol), pent-1-yne (2.52 g, 37.0 mmol), sodium (R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate (0.037 g, 0.185 mmol) and copper (II) sulfate (5.90 mg, 0.037 mmol) were added in a mixture of 1:2 (v/v) solution of water:butanol, yielding a product of 1-((3-(2-methoxyethoxy)propoxy)methyl)-4-propyl-1H-1,2,3-triazole.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-azido-2-(2-(2-methoxyethoxy)ethoxy)ethane (15.0 g, 79 mmol) was mixed with phenylacetylene (8.10 g, 79 mmol) in a 1:3 solution of water:butanol. The mixture was rotovap and the product extracted in ethanolamine and washed multiple times with water and brine, producing 1-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)-4-phenyl-1H-1,2,3-triazole. the product extracted in ethanolamine washed multiple times with water and brine

反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Sodium azide (5.37 g, 83 mmol) and 2-(2-(2-methoxyethoxy)ethoxy)ethyl methanesulfonate (20 g, 83 mmol) were added without solvent, the temperature was raised to 60° C. and the mixture stirred for 48 hours. The salts were filtered and ethyl acetate added to precipitate the dissolved salts and filtered again, producing 1-azido-2-(2-(2-methoxyethoxy)ethoxy)ethane. The salts were filtered ethyl acetate added to precipitate the dissolved salts filtered again

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-azido-2-(2-(2-methoxyethoxy)ethoxy)ethane (7.0 g, 37.0 mmol), pent-1-yne (2.52 g, 37.0 mmol), sodium (R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate (0.037 g, 0.19 mmol) and copper (II) sulfate (5.90 mg, 0.037 mmol) were added in a mixture of 1:2 (v/v) solution of water:butanol, yielding a product of 1-((3-(2-methoxyethoxy)propoxy)methyl)-4-propyl-1H-1,2,3-triazole.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 1-azido-2-(2-(2-methoxyethoxy)ethoxy)ethane (15.0 g, 79 mmol) was mixed with phenylacetylene (8.10 g, 79 mmol) in a 1:3 solution of water:butanol. The mixture was rotovap and the product extracted in ethanolamine and washed multiple times with water and brine, producing 1-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)-4-phenyl-1H-1,2,3-triazole. the product extracted in ethanolamine washed multiple times with water and brine

反応条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Sodium azide (5.37 g, 83 mmol) and 2-(2-(2-methoxyethoxy)ethoxy)ethyl methanesulfonate (20 g, 83 mmol) were added without solvent, the temperature was raised to 60° C. and the mixture stirred for 48 hours. The salts were filtered and ethyl acetate added to precipitate the dissolved salts and filtered again, producing 1-azido-2-(2-(2-methoxyethoxy)ethoxy)ethane. The salts were filtered ethyl acetate added to precipitate the dissolved salts filtered again