N-(5-amino-2-fluorophenyl)acetamide

反応条件: temp:130.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 26.56 g (0.1579 mol) of 2-(N-acetylamino)-4-amino-1-fluorobenzene, 35.89 ml (0.1776 mol) of diethyl ethoxymethylenemalonate, and 30 ml of toluene is stirred at 130° C. for 3 hours. After cooling, the precipitate which forms is triturated with ether to yield 50.64 g (94.8%) of title compound as a white solid: After cooling the precipitate which forms is triturated with ether

反応条件: temp:5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of sodium nitrite (17.3 g) in water (40 mL) was added dropwise to a mixture of N-(5-amino-2-fluorophenyl)acetamide (36.7 g), sulfuric acid (50 mL) and water (270 mL) at 0-10° C. The mixture was stirred at 0-10° C. for 20 minutes and then a solution of urea (2.0 g) in water (20 mL) was added and the resulting mixture stirred at 0-10° C. for a further 20 minutes. The mixture was added dropwise over a period 75 minutes to a stirred solution of copper sulfate pentahydrate (131 g) in water (110 mL) at 130° C. and the resulting mixture heated at 130° C. for 2.5 hours. The mixture was cooled in an ice bath and the pH of the solution adjusted to 14 by the addition of 30% aqueous sodium hydroxide solution. The mixture was filtered through hyflo, washing with water. The pH of the filtrate was acidified by the addition of concentrated hydrochloric acid and extracted with ethyl acetate. The combined extracts were dried over magnesium sulfate and the solvent removed under reduced pressure to afford title compound as a brown solid, 22.1 g. the resulting mixture stirred at 0-10° C. for a further 20 minutes the resulting mixture heated at 130° C. for 2.5 hours The mixture was cooled in an ice bath The mixture was filtered through hyflo washing with water The pH of the filtrate was acidified by the addition of concentrated hydrochloric acid extracted with ethyl acetate The combined extracts were dried over magnesium sulfate the solvent removed under reduced pressure

反応条件: temp:5.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of sodium nitrite (17.3 g) in water (40 mL) was added dropwise to a mixture of N-(5-amino-2-fluorophenyl)acetamide (36.7 g), sulfuric acid (50 mL) and water (270 mL) at 0-10° C. The mixture was stirred at 0-10° C. for 20 minutes and then a solution of urea (2.0 g) in water (20 mL) was added and the resulting mixture stirred at 0-10° C. for a further 20 minutes. The mixture was added dropwise over a period 75 minutes to a stirred solution of copper sulfate pentahydrate (131 g) in water (110 mL) at 130° C. and the resulting mixture heated at 130° C. for 2.5 hours. The mixture was cooled in an ice bath and the pH of the solution adjusted to 14 by the addition of 30% aqueous sodium hydroxide solution. The mixture was filtered through hyflo, washing with water. The pH of the filtrate was acidified by the addition of concentrated hydrochloric acid and extracted with ethyl acetate. The combined extracts were dried over magnesium sulfate and the solvent removed under reduced pressure to afford title compound as a brown solid, 22.1 g. the resulting mixture stirred at 0-10° C. for a further 20 minutes the resulting mixture heated at 130° C. for 2.5 hours The mixture was cooled in an ice bath The mixture was filtered through hyflo washing with water The pH of the filtrate was acidified by the addition of concentrated hydrochloric acid extracted with ethyl acetate The combined extracts were dried over magnesium sulfate the solvent removed under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 2-fluoro-5-nitrophenylamine (2.0 g), palladium, 10 wt. % on activated carbon (0.10 g) and ethanol (20 mL) were stirred at room temperature for 2 hours under an atmosphere of hydrogen. The mixture was filtered through hyflo, washing with ethanol and the solvent removed under reduced pressure to afford title compound as a white solid, 1.7 g. The mixture was filtered through hyflo washing with ethanol the solvent removed under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 2-fluoro-5-nitrophenylamine (2.0 g), palladium, 10 wt. % on activated carbon (0.10 g) and ethanol (20 mL) were stirred at room temperature for 2 hours under an atmosphere of hydrogen. The mixture was filtered through hyflo, washing with ethanol and the solvent removed under reduced pressure to afford title compound as a white solid, 1.7 g. The mixture was filtered through hyflo washing with ethanol the solvent removed under reduced pressure

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A mixture of 2-fluoro-5-nitrophenylamine (2.0 g), palladium, 10 wt. % on activated carbon (0.10 g) and ethanol (20 mL) were stirred at room temperature for 2 hours under an atmosphere of hydrogen. The mixture was filtered through hyflo, washing with ethanol and the solvent removed under reduced pressure to afford title compound as a white solid, 1.7 g. The mixture was filtered through hyflo washing with ethanol the solvent removed under reduced pressure