2-chloro-4-iodo-1-methoxybenzene

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Prepare according to the general procedure outlined in EXAMPLE 72 using 2-chloro-4-iodo-1-methoxybenzene (520 mg, 19 mmol) and 5-trimethylsilanylethynyl-nicotinonitrile (350 mg, 1.75 mmol), (prepared as described in PREPARATION 3), to give the title compound (820 mg, 47%). Prepare

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Prepare according to the general procedure outlined in EXAMPLE 72 using 2-chloro-4-iodo-1-methoxybenzene (520 mg, 19 mmol) and 5-trimethylsilanylethynyl-nicotinonitrile (350 mg, 1.75 mmol), (prepared as described in PREPARATION 3), to give the title compound (820 mg, 47%). Prepare

反応条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a stirring mixture of 3-chloro-4-methoxyiodobenzene (0.3 g, 1.1 mmol), (PPh3)2PdCl2 (31 mg, 0.044 mmol), triethylamine (1.2 mL, 8.9 mmol) in dimethylformamide (3 mL) was added to phenylethynylcarbinol (0.29 g, 2.2 mmol) at temperature in the range of 20-40° C. under nitrogen atmosphere. The mixture was then stirred at 80° C. for 12 hours. After cooling the mixture to temperature in the range of 20-40° C. it was diluted with water (15 mL) and extracted with ethyl acetate (3×25 mL). The organic layers were collected, combined, washed with water (2×5 mL), dried over anhydrous sodium sulphate, and concentrated to give the desired compound. After cooling the mixture to temperature in the range of 20-40° C. it extracted with ethyl acetate (3×25 mL) The organic layers were collected washed with water (2×5 mL) dried over anhydrous sodium sulphate concentrated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Prepare according to the general procedure outlined in EXAMPLE 72 using 2-chloro-4-iodo-1-methoxybenzene (520 mg, 19 mmol) and 5-trimethylsilanylethynyl-nicotinonitrile (350 mg, 1.75 mmol), (prepared as described in PREPARATION 3), to give the title compound (820 mg, 47%). Prepare