3-chlorosulfonylpropyl acetate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using 3-acetoxypropane-1-sulfonyl chloride and 1-methylpiperazine, the same reaction as in Reference Example 44 and 46 was conducted to produce the title compound. m.p. 90°-93° C. the same reaction as in Reference Example 44 and 46

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using 3-acetoxypropane-1-sulfonyl chloride and dimethylamine hydrochloride, the same reaction as in Reference Example 44 and 46 was conducted to produce the title compound. the same reaction as in Reference Example 44 and 46

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using 3-acetoxypropane-1-sulfonyl chloride and dimethylamine hydrochloride, the same reaction as in Reference Example 44 and 46 was conducted to produce the title compound. the same reaction as in Reference Example 44 and 46

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using 3-acetoxypropane-1-sulfonyl chloride and 1-methylpiperazine, the same reaction as in Reference Example 44 and 46 was conducted to produce the title compound. m.p. 90°-93° C. the same reaction as in Reference Example 44 and 46

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using 3-acetoxypropane-1-sulfonyl chloride and dimethylamine hydrochloride, the same reaction as in Reference Example 44 and 46 was conducted to produce the title compound. the same reaction as in Reference Example 44 and 46

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using 3-acetoxy-1-propanesulfonylchloride and dimethylamine, substantially the same reaction was conducted as in reference example 47 and 48 to produce the title compound. substantially the same reaction

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 15 g of 3-acetoxy-1-propanesulfonylchloride was dissolved in 150 ml dichloromethane. To the mixture was added dropwise 11.6 g of methylamine (40% methanol solution) with stirring under ice coioling. The reaction mixture was stirred for 1.5 hours under ice cooling. The reaction mixture was stirred for 1.5 hours under ice cooling

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 15 g of 3-acetoxy-1-propanesulfonylchloride was dissolved in 150 ml dichloromethane. To the mixture was added dropwise 11.6 g of methylamine (40% methanol solution) with stirring under ice coioling. The reaction mixture was stirred for 1.5 hours under ice cooling. The reaction mixture was stirred for 1.5 hours under ice cooling

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 15 g of 3-acetoxy-1-propanesulfonylchloride was dissolved in 150 ml dichloromethane. To the mixture was added dropwise 11.6 g of methylamine (40% methanol solution) with stirring under ice coioling. The reaction mixture was stirred for 1.5 hours under ice cooling. The reaction mixture was stirred for 1.5 hours under ice cooling

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A 100 g (0.48 mol) portion of phosphorus pentachloride is added to a flask containing 82.0 g (0.4 mol) of the above sulfonic acid salt. When the initial reaction subsides, the mixture is heated on the steam bath for 1 hr and 25 g of phosphorus pentachloride is added. Heating is continued for another 2.5 hr and another 10 g of phosphorus pentachloride is added and heating continued for 30 min. The dark reaction mixture is cooled and filtered and the filtrate distilled. The clear distillate is redistilled to give 42.3 g of 3-acetyloxy-1-propanesulfonyl chloride; bp 69°-81°/0.03 mm. When the initial reaction subsides the mixture is heated on the steam bath for 1 hr Heating heating continued for 30 min The dark reaction mixture is cooled filtered the filtrate distilled The clear distillate is redistilled

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using 3-acetoxypropane-1-sulfonyl chloride and 1-methylpiperazine, the same reaction as in Reference Example 44 and 46 was conducted to produce the title compound. m.p. 90°-93° C. the same reaction as in Reference Example 44 and 46

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using 3-acetoxypropane-1-sulfonyl chloride and dimethylamine hydrochloride, the same reaction as in Reference Example 44 and 46 was conducted to produce the title compound. the same reaction as in Reference Example 44 and 46