(2S,4S)-4-hydroxypyrrolidine-2-carboxamide;hydrochloride

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with (2S,4S)-4-hydroxypyrrolidine-2-carboxamide hydrochloride (851233-67-5) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=397.5 [MH+].

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with (2S,4S)-4-hydroxypyrrolidine-2-carboxamide hydrochloride (851233-67-5) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=397.5 [MH+].

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with (2S,4S)-4-hydroxypyrrolidine-2-carboxamide hydrochloride (851233-67-5) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=397.5 [MH+].