2-[(2R)-4-benzylpiperazin-2-yl]ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of Example 255D (9.2 g, 33.3 mmol) in tetrahydrofuran (150 mL) at 0° C. was added lithium aluminum hydride (2 M, tetrahydrofuran, 50 mL) dropwise. The solution was allowed to warm to room temperature and stirred for 16 hours. Water (3.8 mL) in tetrahydrofuran (25 mL) was added dropwise to the solution followed by 3.8 mL NaOH (15% aqueous) and more water (11.4 mL). The solids were removed via filtration. Purification via flash chromatography (0-30% methanol/dichloromethane) afforded the title compound. The solids were removed via filtration Purification via flash chromatography (0-30% methanol/dichloromethane)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of Example 255D (9.2 g, 33.3 mmol) in tetrahydrofuran (150 mL) at 0° C. was added lithium aluminum hydride (2 M, tetrahydrofuran, 50 mL) dropwise. The solution was allowed to warm to room temperature and stirred for 16 hours. Water (3.8 mL) in tetrahydrofuran (25 mL) was added dropwise to the solution followed by 3.8 mL NaOH (15% aqueous) and more water (11.4 mL). The solids were removed via filtration. Purification via flash chromatography (0-30% methanol/dichloromethane) afforded the title compound. The solids were removed via filtration Purification via flash chromatography (0-30% methanol/dichloromethane)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of Example 255D (9.2 g, 33.3 mmol) in tetrahydrofuran (150 mL) at 0° C. was added lithium aluminum hydride (2 M, tetrahydrofuran, 50 mL) dropwise. The solution was allowed to warm to room temperature and stirred for 16 hours. Water (3.8 mL) in tetrahydrofuran (25 mL) was added dropwise to the solution followed by 3.8 mL NaOH (15% aqueous) and more water (11.4 mL). The solids were removed via filtration. Purification via flash chromatography (0-30% methanol/dichloromethane) afforded the title compound. The solids were removed via filtration Purification via flash chromatography (0-30% methanol/dichloromethane)