2-(4-aminopiperidin-1-yl)-N,N-dimethylacetamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for the synthesis of the compound 16 using HATU except that 2-(4-aminopiperidin-1-yl)-N,N-dimethylacetamide was used. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.46-2.17 (m, 14H) 2.94 (d, J=10.61 Hz, 6H) 3.01-3.20 (m, 2H) 3.33 (s, 3H) 4.06 (t, J=13.89 Hz, 5H) 4.24 (d, J=4.55 Hz, 2H) 4.78 (t, J=7.45 Hz, 1H) 7.43-7.62 (m, 2H) 8.06 (br. s., 1H) 8.27 (s, 2H) 8.36 (d, J=7.07 Hz, 1H) 9.52 (br. s., 1H) [M+H] calc'd for C30H40F2N8O4, 614. found 614. The final compound was purified by reverse phase HPLC to give the free base

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for the synthesis of the compound 16 using HATU except that 2-(4-aminopiperidin-1-yl)-N,N-dimethylacetamide was used. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.46-2.17 (m, 14 H) 2.94 (d, J=10.61 Hz, 6 H) 3.01-3.20 (m, 2 H) 3.33 (s, 3 H) 4.06 (t, J=13.89 Hz, 5 H) 4.24 (d, J=4.55 Hz, 2 H) 4.78 (t, J=7.45 Hz, 1 H) 7.43-7.62 (m, 2 H) 8.06 (br. s., 1 H) 8.27 (s, 2 H) 8.36 (d, J=7.07 Hz, 1 H) 9.52 (br. s., 1 H) [M+H] calc'd for C30H40F2N8O4, 614; found 614. The final compound was purified by reverse phase HPLC to give the free base

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for the synthesis of the compound 16 using HATU except that 2-(4-aminopiperidin-1-yl)-N,N-dimethylacetamide was used. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.46-2.17 (m, 14H) 2.94 (d, J=10.61 Hz, 6H) 3.01-3.20 (m, 2H) 3.33 (s, 3H) 4.06 (t, J=13.89 Hz, 5H) 4.24 (d, J=4.55 Hz, 2H) 4.78 (t, J=7.45 Hz, 1H) 7.43-7.62 (m, 2H) 8.06 (br. s., 1H) 8.27 (s, 2H) 8.36 (d, J=7.07 Hz, 1H) 9.52 (br. s., 1H) [M+H] calc'd for C30H40F2N8O4, 614. found 614. The final compound was purified by reverse phase HPLC to give the free base