2-chloro-5-fluorobenzamide

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 4.06 g (0.02 mol) of 4-trifluoromethoxy-phenyl isocyanate in 10 ml of dry toluene is added to 3.48 g (0.02 mol) of 2-chloro-5-fluorobenzamide in 100 ml of dry toluene, at 100° C., in the absence of moisture. The mixture is boiled under reflux for 10 hours. After it has been cooled, the precipitated product is filtered off under suction and rinsed with methanol. 6.2 g (82.5% of theory) of 1-(2-chloro-5-fluoro-benzoyl)-3-(4-trifluoromethoxyphenyl)-urea of melting point 199° C. are obtained. The compound is identical to the compound prepared by process variant (a). under reflux for 10 hours After it has been cooled the precipitated product is filtered off under suction rinsed with methanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 4.06 g (0.02 mol) of 4-trifluoromethoxy-phenyl isocyanate in 10 ml of dry toluene is added to 3.48 g (0.02 mol) of 2-chloro-5-fluorobenzamide in 100 ml of dry toluene, at 100° C., in the absence of moisture. The mixture is boiled under reflux for 10 hours. After it has been cooled, the precipitated product is filtered off under suction and rinsed with methanol. 6.2 g (82.5% of theory) of 1-(2-chloro-5-fluoro-benzoyl)-3-(4-trifluoromethoxyphenyl)-urea of melting point 199° C. are obtained. The compound is identical to the compound prepared by process variant (a). under reflux for 10 hours After it has been cooled the precipitated product is filtered off under suction rinsed with methanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: The same method as in Example 3 was conducted using 2,6-dimethyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 2) instead of 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) and was conducted using 3-carbamoyl-4-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound. to give the objective compound

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 4.06 g (0.02 mol) of 4-trifluoromethoxy-phenyl isocyanate in 10 ml of dry toluene is added to 3.48 g (0.02 mol) of 2-chloro-5-fluorobenzamide in 100 ml of dry toluene, at 100° C., in the absence of moisture. The mixture is boiled under reflux for 10 hours. After it has been cooled, the precipitated product is filtered off under suction and rinsed with methanol. 6.2 g (82.5% of theory) of 1-(2-chloro-5-fluoro-benzoyl)-3-(4-trifluoromethoxyphenyl)-urea of melting point 199° C. are obtained. The compound is identical to the compound prepared by process variant (a). under reflux for 10 hours After it has been cooled the precipitated product is filtered off under suction rinsed with methanol