methyl (3S)-4-amino-3-hydroxybutanoate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 2.50 g (14.7 mmol) of (S)-4-amino-3-hydroxy-butyric acid methyl ester; HCl (intermediate 24) in 18 ml of methanol was treated with 6.19 g (73.7 mmol) of natriumhydrogencarbonat, 2.2 ml (14.7 mmol) of dimethoxyacetaldehyde (in H2O 60%), 0.250 g of Pd/C (10%) and was stirred over H2-atmosphere for 4 h. After filtration, the solution was evaporated, dissolved in toluene, evaporated under reduced pressure (2×) to yield 3.781 g (70%) of the titled compound as yellow oil. MS: 222.13 (MH+). After filtration the solution was evaporated dissolved in toluene evaporated under reduced pressure (2×)