2-methylidenepropanedinitrile

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 14 (5.07 g, 17.0 mmol) and diisopropylethylamine (4.97 g, 38.4 mmol) in DMF (40 nL) was treated with a solution of 2-cyanoacrylonitrile (2.30 g, 26.3 mmol) in DMP (40 mL) at room temperature (14 d). The solvent was removed in vacuo and the residue dissolved in dichloromethane and washed with water, brine, and dried (Na2SO4). Concentrated in vacuo, the residue was recrystallized from ethanol to afford 15 as white crystals. The solvent was removed in vacuo the residue dissolved in dichloromethane washed with water, brine dried (Na2SO4) Concentrated in vacuo the residue was recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 14 (5.07 g, 17.0 mmol) and diisopropylethylamine (4.97 g, 38.4 mmol) in DMF (40 nL) was treated with a solution of 2-cyanoacrylonitrile (2.30 g, 26.3 mmol) in DMP (40 mL) at room temperature (14 d). The solvent was removed in vacuo and the residue dissolved in dichloromethane and washed with water, brine, and dried (Na2SO4). Concentrated in vacuo, the residue was recrystallized from ethanol to afford 15 as white crystals. The solvent was removed in vacuo the residue dissolved in dichloromethane washed with water, brine dried (Na2SO4) Concentrated in vacuo the residue was recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 3 (5.07 g, 17.0 mmol) and diisopropylethylamine (4.97 g, 38.4 mmol) in DMF (40 mL) was treated with a solution of 2-cyanoacrylonitrile (2.30 g, 26.3 mmol) in DMF (40 mL) at room temperature (14 d). The solvent was removed in vacuo and the residue dissolved in dichloromethane and washed with water, brine, and dried (Na2SO4). Concentrated in vacuo, the residue was recrystallized from ethanol to afford 4 as white crystals. The solvent was removed in vacuo the residue dissolved in dichloromethane washed with water, brine dried (Na2SO4) Concentrated in vacuo the residue was recrystallized from ethanol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A solution of 14 (5.07 g, 17.0 mmol) and diisopropylethylamine (4.97 g, 38.4 mmol) in DMF (40 nL) was treated with a solution of 2-cyanoacrylonitrile (2.30 g, 26.3 mmol) in DMP (40 mL) at room temperature (14 d). The solvent was removed in vacuo and the residue dissolved in dichloromethane and washed with water, brine, and dried (Na2SO4). Concentrated in vacuo, the residue was recrystallized from ethanol to afford 15 as white crystals. The solvent was removed in vacuo the residue dissolved in dichloromethane washed with water, brine dried (Na2SO4) Concentrated in vacuo the residue was recrystallized from ethanol