tert-butyl N-[(3S)-1-methyl-2-oxopyrrolidin-3-yl]carbamate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-Butyl 1-methyl-2-oxopyrrolidin-3-ylcarbamate (prepared according to Example 10; 300 mg, 1.40 mmol) was dissolved in 4M hydrogen chloride in dioxane (3.5 mL, 14 mmol), and the reaction was allowed to stir at ambient temperature for 16 hours. The reaction mixture was concentrated to yield (S)-3-amino-1-methylpyrrolidin-2-one hydrochloride (211 mg, 100%) which was taken onto the next step without purification. The reaction mixture was concentrated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-butyl 1-methyl-2-oxopyrrolidin-3-ylcarbamate was prepared from compound (S)-tert-butyl 2-oxopyrrolidin-3-ylcarbamate (Example 6) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 25% acetone/hexanes to provide compound (2a) in 45% yield. The crude product was purified by column chromatography eluting with 25% acetone/hexanes

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-butyl 1-methyl-2-oxopyrrolidin-3-ylcarbamate was prepared from compound (S)-tert-butyl 2-oxopyrrolidin-3-ylcarbamate (Example 6) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 25% acetone/hexanes to provide compound (2a) in 45% yield. The crude product was purified by column chromatography eluting with 25% acetone/hexanes

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-Butyl 1-methyl-2-oxopyrrolidin-3-ylcarbamate (prepared according to Example 10; 300 mg, 1.40 mmol) was dissolved in 4M hydrogen chloride in dioxane (3.5 mL, 14 mmol), and the reaction was allowed to stir at ambient temperature for 16 hours. The reaction mixture was concentrated to yield (S)-3-amino-1-methylpyrrolidin-2-one hydrochloride (211 mg, 100%) which was taken onto the next step without purification. The reaction mixture was concentrated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-butyl 1-methyl-2-oxopyrrolidin-3-ylcarbamate was prepared from compound (S)-tert-butyl 2-oxopyrrolidin-3-ylcarbamate (Example 6) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 25% acetone/hexanes to provide compound (2a) in 45% yield. The crude product was purified by column chromatography eluting with 25% acetone/hexanes