methyl 2-[2-(2,2-dimethoxyethyl)-3-oxocyclopentyl]acetate

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:45.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In a 4 liter jacketed reactor, a mixture of 1,236 liter of AcOH and 1,236 liter of water was heated to 45° C. Then to this mixture were added 494 g of methyl [2-(2,2-dimethoxyethyl)-3-oxocyclopentyl]acetate. The resulting reaction medium was stirred at 46-49° C. until completion of the conversion of the acetal to aldehyde. Distillation under vacuum allowed for the direct isolation of the purified title compound with a yield of 89% (overall yield from Example 1: 66%). The resulting reaction medium Distillation under vacuum purified title compound with a yield of 89% (overall yield from Example 1: 66%)

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: In a 3-neck 250 ml round bottom flask equipped with a short path distillation apparatus, a solution of 80.0 g of dimethyl [2-(2,2-dimethoxyethyl)-3-oxocyclopentyl]malonate and 63.0 g NMP was heated to 160° C. The solution was then charged with water until the reaction was complete. Upon completion of the reaction, distillation under vacuum (b.p.=140-145° C. at 1 mbar) of the reaction medium allowed to recover directly the purified title compound with a yield of 81%. In a 3-neck 250 ml round bottom flask equipped with a short path distillation apparatus Upon completion of the reaction, distillation under vacuum (b.p.=140-145° C. at 1 mbar) of the reaction medium to recover directly the purified title compound with a yield of 81%