5,5-dimethyl-4-pyrrolidin-1-ylfuran-2-one

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness

反応条件: temp:88.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%. The mixture was cooled to room temp. extracted with CHCl3 (10×15 mL) dried over Na2SO4 evaporated to dryness