2,2-dimethylpropyl (2S)-2-aminopropanoate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates, the tosylate salt of (S)-neopentyl 2-aminopropanoate (2.00 g, 6.03 mmol), phenyl phosphorodichloridate (0.90 mL, 12.06 mmol) and TEA (1.68 mL, 12.06 mmol) were combined in 66 mL of dry DCM. The product, (2S)-neopentyl 2-(chloro(phenoxy)phosphorylamino)propanoate was obtained as a clear, thick oil (1.91 g, 95%). for synthesizing naphthyl (amino acid ester) phosphorochloridates

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates and tosylate salt of (S)-neopentyl 2-aminopropanoate (1.0 g, 2.8 mmol), (S)-methyl 2-(6-(dichlorophosphoryloxy)naphthalen-2-yl)propanoate (990 mg, 2.8 mmol), TEA (0.8 mL, 5.6 mmol) and DCM (20 mL) were combined to give 1.13 g of desired (2S)-methyl 2-(6-(chloro((S)-1-(neopentyloxy)-1-oxopropan-2-ylamino)phosphoryloxy)naphthalen-2-yl)propanoate in 83% yield as a gummy syrup.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates, the tosylate salt of (S)-neopentyl 2-aminopropanoate (2.00 g, 6.03 mmol), phenyl phosphorodichloridate (0.90 mL, 12.06 mmol) and TEA (1.68 mL, 12.06 mmol) were combined in 66 mL of dry DCM. The product, (2S)-neopentyl 2-(chloro(phenoxy)phosphorylamino)propanoate was obtained as a clear, thick oil (1.91 g, 95%). for synthesizing naphthyl (amino acid ester) phosphorochloridates

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates and tosylate salt of (S)-neopentyl 2-aminopropanoate (1.0 g, 2.8 mmol), (S)-methyl 2-(6-(dichlorophosphoryloxy)naphthalen-2-yl)propanoate (990 mg, 2.8 mmol), TEA (0.8 mL, 5.6 mmol) and DCM (20 mL) were combined to give 1.13 g of desired (2S)-methyl 2-(6-(chloro((S)-1-(neopentyloxy)-1-oxopropan-2-ylamino)phosphoryloxy)naphthalen-2-yl)propanoate in 83% yield as a gummy syrup.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates and tosylate salt of (S)-neopentyl 2-aminopropanoate (1.0 g, 2.8 mmol), (S)-methyl 2-(6-(dichlorophosphoryloxy)naphthalen-2-yl)propanoate (990 mg, 2.8 mmol), TEA (0.8 mL, 5.6 mmol) and DCM (20 mL) were combined to give 1.13 g of desired (2S)-methyl 2-(6-(chloro((S)-1-(neopentyloxy)-1-oxopropan-2-ylamino)phosphoryloxy)naphthalen-2-yl)propanoate in 83% yield as a gummy syrup.

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates, the tosylate salt of (S)-neopentyl 2-aminopropanoate (2.00 g, 6.03 mmol), phenyl phosphorodichloridate (0.90 mL, 12.06 mmol) and TEA (1.68 mL, 12.06 mmol) were combined in 66 mL of dry DCM. The product, (2S)-neopentyl 2-(chloro(phenoxy)phosphorylamino)propanoate was obtained as a clear, thick oil (1.91 g, 95%). for synthesizing naphthyl (amino acid ester) phosphorochloridates

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates and tosylate salt of (S)-neopentyl 2-aminopropanoate (1.0 g, 2.8 mmol), (S)-methyl 2-(6-(dichlorophosphoryloxy)naphthalen-2-yl)propanoate (990 mg, 2.8 mmol), TEA (0.8 mL, 5.6 mmol) and DCM (20 mL) were combined to give 1.13 g of desired (2S)-methyl 2-(6-(chloro((S)-1-(neopentyloxy)-1-oxopropan-2-ylamino)phosphoryloxy)naphthalen-2-yl)propanoate in 83% yield as a gummy syrup.