methyl 2-(2,4-difluorophenyl)acetate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Sulfuric acid (3.35 mL) was added to a stirred solution of 2,4-difluorophenylacetic acid ([CAS 81228-09-3], 3.5 g, 20.33 mmol) in MeOH (70 mL) at RT. The mixture was stirred at reflux for 18 h. The methanol was removed in vacuo. The residue was diluted with EtOAc and washed successively with H2O, sat. aq. NaHCO3 and brine. The organic layer was separated, dried (Na2SO4), filtered and the solvent evaporated in vacuo to yield I-24 (3.34 g, 88%) as a light yellow oil. at reflux for 18 h The methanol was removed in vacuo The residue was diluted with EtOAc washed successively with H2O, sat. aq. NaHCO3 and brine The organic layer was separated dried (Na2SO4) filtered the solvent evaporated in vacuo to yield I-24 (3.34 g, 88%) as a light yellow oil

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Sulfuric acid (3.35 mL) was added to a stirred solution of 2,4-difluorophenylacetic acid ([CAS 81228-09-3], 3.5 g, 20.33 mmol) in MeOH (70 mL) at RT. The mixture was stirred at reflux for 18 h. The methanol was removed in vacuo. The residue was diluted with EtOAc and washed successively with H2O, sat. aq. NaHCO3 and brine. The organic layer was separated, dried (Na2SO4), filtered and the solvent evaporated in vacuo to yield I-24 (3.34 g, 88%) as a light yellow oil. at reflux for 18 h The methanol was removed in vacuo The residue was diluted with EtOAc washed successively with H2O, sat. aq. NaHCO3 and brine The organic layer was separated dried (Na2SO4) filtered the solvent evaporated in vacuo to yield I-24 (3.34 g, 88%) as a light yellow oil