tert-butyl N-[(3S)-1-methyl-2-oxopiperidin-3-yl]carbamate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-Butyl 1-methyl-2-oxopiperidin-3-ylcarbamate (prepared according to Example 12; 78 mg, 0.34 mmol) was dissolved in 4M hydrogen chloride in dioxane (1.7 mL, 6.8 mmol), and the reaction was allowed to stir at ambient temperature for 16 hours. The reaction mixture was concentrated to yield (S)-3-amino-1-methylpiperidin-2-one hydrochloride (56 mg, 100%), which was taken on to the next step without further purification. The reaction mixture was concentrated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-butyl 1-methyl-2-oxopiperidin-3-ylcarbamate was prepared from (S)-tert-butyl 2-oxopiperidin-3-ylcarbamate (Example 7) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 100% ethyl acetate, to provide compound (2c) in 31% yield. The crude product was purified by column chromatography eluting with 100% ethyl acetate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-butyl 1-methyl-2-oxopiperidin-3-ylcarbamate was prepared from (S)-tert-butyl 2-oxopiperidin-3-ylcarbamate (Example 7) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 100% ethyl acetate, to provide compound (2c) in 31% yield. The crude product was purified by column chromatography eluting with 100% ethyl acetate

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-Butyl 1-methyl-2-oxopiperidin-3-ylcarbamate (prepared according to Example 12; 78 mg, 0.34 mmol) was dissolved in 4M hydrogen chloride in dioxane (1.7 mL, 6.8 mmol), and the reaction was allowed to stir at ambient temperature for 16 hours. The reaction mixture was concentrated to yield (S)-3-amino-1-methylpiperidin-2-one hydrochloride (56 mg, 100%), which was taken on to the next step without further purification. The reaction mixture was concentrated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: (S)-tert-butyl 1-methyl-2-oxopiperidin-3-ylcarbamate was prepared from (S)-tert-butyl 2-oxopiperidin-3-ylcarbamate (Example 7) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 100% ethyl acetate, to provide compound (2c) in 31% yield. The crude product was purified by column chromatography eluting with 100% ethyl acetate