2-aminododecan-1-ol

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 2 g of 2-aminododecanol, 3 g of triethylamine in 50 ml of dichloromethane is added 3.5 g of octanoyl chloride. The reaction mixture is stirred overnight and then quenched by pouring into ice. This is extracted with dichloromethane and the organic solution is washed with aqueous bicarbonate solution, water and brine. The organic phase is dried over magnesium sulfate, filtered and concentrated to give 3.8 g of the product. quenched by pouring into ice This is extracted with dichloromethane the organic solution is washed with aqueous bicarbonate solution, water and brine The organic phase is dried over magnesium sulfate filtered concentrated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 26.465 g of 2-aminododecanol and 12.32 g of ethylene carbonate were heated at approximately 110° C. for 48 hours (preparation of the cyclic urethanes can be carried out without a solvent or in toluene solution)as a solvent. The reaction was followed by tlc and at the completion of the reaction the contents were cooled, dissolved in ethyl acetate and the organic solution was washed with brine and water. After drying, the filtrate was concentrated and the oily residue was kugelrohr distilled to give 27.33 g (96.56%) of colorless liquid, which slowly solidified, m.p. 31.5-32.5° C. at the completion of the reaction the contents were cooled the organic solution was washed with brine and water After drying the filtrate was concentrated the oily residue was kugelrohr distilled

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 2 g of 2-aminododecanol, 3 g of triethylamine in 50 ml of dichloromethane is added 3.5 g of octanoyl chloride. The reaction mixture is stirred overnight and then quenched by pouring into ice. This is extracted with dichloromethane and the organic solution is washed with aqueous bicarbonate solution, water and brine. The organic phase is dried over magnesium sulfate, filtered and concentrated to give 3.8 g of the product. quenched by pouring into ice This is extracted with dichloromethane the organic solution is washed with aqueous bicarbonate solution, water and brine The organic phase is dried over magnesium sulfate filtered concentrated

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: 26.465 g of 2-aminododecanol and 12.32 g of ethylene carbonate were heated at approximately 110° C. for 48 hours (preparation of the cyclic urethanes can be carried out without a solvent or in toluene solution)as a solvent. The reaction was followed by tlc and at the completion of the reaction the contents were cooled, dissolved in ethyl acetate and the organic solution was washed with brine and water. After drying, the filtrate was concentrated and the oily residue was kugelrohr distilled to give 27.33 g (96.56%) of colorless liquid, which slowly solidified, m.p. 31.5-32.5° C. at the completion of the reaction the contents were cooled the organic solution was washed with brine and water After drying the filtrate was concentrated the oily residue was kugelrohr distilled

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: To a solution of 2 g of 2-aminododecanol, 3 g of triethylamine in 50 ml of dichloromethane is added 3.5 g of octanoyl chloride. The reaction mixture is stirred overnight and then quenched by pouring into ice. This is extracted with dichloromethane and the organic solution is washed with aqueous bicarbonate solution, water and brine. The organic phase is dried over magnesium sulfate, filtered and concentrated to give 3.8 g of the product. quenched by pouring into ice This is extracted with dichloromethane the organic solution is washed with aqueous bicarbonate solution, water and brine The organic phase is dried over magnesium sulfate filtered concentrated