N,N-dimethylpiperazine-1-sulfonamide

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Compound 112 was prepared by the procedure described for the synthesis of compound 104 by replacing 2-cyanoethylamine with N,N-dimethylpiperazine-1-sulfonamide. LCMS (+ESI) m/z=569.4 [M+H]+. 1H NMR (CDCl3) δ 7.92 (d, J=9.6 Hz, 1H), 7.48-7.52 (m, 1H), 7.28-7.32 (m, 1H), 7.19-7.26 (m, 1H), 4.81-4.84 (m, 3H), 3.91-3.98 (m, 3H), 3.81-3.86 (m, 1H), 3.65-3.71 (m, 1H), 3.53-3.60 (m, 1H), 3.29-3.47 (m, 2H), 3.16-3.26 (m, 4H), 2.85 (s, 6H), 1.12 (s, 9H).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Compound 112 was prepared by the procedure described for the synthesis of compound 104 by replacing 2-cyanoethylamine with N,N-dimethylpiperazine-1-sulfonamide. LCMS (+ESI) m/z=569.4 [M+H]+. 1H NMR (CDCl3) δ 7.92 (d, J=9.6 Hz, 1H), 7.48-7.52 (m, 1H), 7.28-7.32 (m, 1H), 7.19-7.26 (m, 1H), 4.81-4.84 (m, 3H), 3.91-3.98 (m, 3H), 3.81-3.86 (m, 1H), 3.65-3.71 (m, 1H), 3.53-3.60 (m, 1H), 3.29-3.47 (m, 2H), 3.16-3.26 (m, 4H), 2.85 (s, 6H), 1.12 (s, 9H).

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Following Example 216, to a well stirred solution of 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid and N,N-dimethylpiperazine-1-sulfonamide were reacted to give 217. MS: (ESI+)=489.1 were reacted

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Following Example 216, to a well stirred solution of 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid and N,N-dimethylpiperazine-1-sulfonamide were reacted to give 217. MS: (ESI+)=489.1 were reacted

反応条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

実験手順: Compound 112 was prepared by the procedure described for the synthesis of compound 104 by replacing 2-cyanoethylamine with N,N-dimethylpiperazine-1-sulfonamide. LCMS (+ESI) m/z=569.4 [M+H]+. 1H NMR (CDCl3) δ 7.92 (d, J=9.6 Hz, 1H), 7.48-7.52 (m, 1H), 7.28-7.32 (m, 1H), 7.19-7.26 (m, 1H), 4.81-4.84 (m, 3H), 3.91-3.98 (m, 3H), 3.81-3.86 (m, 1H), 3.65-3.71 (m, 1H), 3.53-3.60 (m, 1H), 3.29-3.47 (m, 2H), 3.16-3.26 (m, 4H), 2.85 (s, 6H), 1.12 (s, 9H).

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir:

反応条件: temp:0.00; pressure:0.00; stir: